<?xml version="1.0" encoding="UTF-8"?><rss xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:content="http://purl.org/rss/1.0/modules/content/" xmlns:atom="http://www.w3.org/2005/Atom" version="2.0"><channel><title><![CDATA[Scala Biodesign]]></title><description><![CDATA[Scala Biodesign]]></description><link>https://www.scala-bio.com/success-stories</link><generator>RSS for Node</generator><lastBuildDate>Tue, 25 Aug 2026 23:50:47 GMT</lastBuildDate><atom:link href="https://www.scala-bio.com/blog-feed.xml" rel="self" type="application/rss+xml"/><item><title><![CDATA[Stabilizing the malaria vaccine protein]]></title><description><![CDATA[Scala’s technology enables heat-stable, low-cost malaria vaccine protein to allow widespread use Why it matters Vaccines intended for widespread use in regions with unreliable electricity and limited cold‑chain infrastructure must be produced in tens of millions of doses and remain stable without refrigeration. Scala’s c omputational stability design strengthens fragile protein subunits by improving their folds from structure and sequence in a single round. RH5 is one example:  stability...]]></description><link>https://www.scala-bio.com/post/copy-of-stabilizing-the-malaria-vaccine-protein</link><guid isPermaLink="false">68c968a95a84d94edbe1bf7f</guid><category><![CDATA[Biotherapeutics]]></category><pubDate>Sun, 02 Nov 2025 14:53:12 GMT</pubDate><enclosure url="https://static.wixstatic.com/media/cecc39_aa02056dc3bb4051a409dde5c1f375a0~mv2.jpg/v1/fit/w_1000,h_1000,al_c,q_80/file.png" length="0" type="image/png"/><dc:creator>gilishklar</dc:creator></item><item><title><![CDATA[Design of a challenging drug target]]></title><description><![CDATA[Scala’s technology stabilizes a dynamic target to accelerate drug discovery In collaboration with: Why it matters Structural information on protein targets is a cornerstone of drug development because it enables researchers to study how potential medicines interact with their targets and to refine those compounds effectively. Boehringer Ingelheim’s structural biology group had struggled for years with a highly dynamic target that could only be expressed in insect cells, where yields were too...]]></description><link>https://www.scala-bio.com/post/design-of-a-challenging-drug-target</link><guid isPermaLink="false">68e3a6a168fa888a144142ba</guid><category><![CDATA[Biotherapeutics]]></category><pubDate>Sat, 01 Nov 2025 12:37:32 GMT</pubDate><enclosure url="https://static.wixstatic.com/media/cecc39_1053996a6b1f4901ba488598ec1cfb9e~mv2.jpg/v1/fit/w_1000,h_1000,al_c,q_80/file.png" length="0" type="image/png"/><dc:creator>gilishklar</dc:creator></item><item><title><![CDATA[Stabilizing glucocerebrosidase (GCase) for Gaucher disease gene therapy]]></title><description><![CDATA[Scala’s underlying technology  enabled thermostable, long-lived enzyme variants that improve survival and brain function in neuronopathic Gaucher disease Why it matters Lysosomal storage disorders are often caused by unstable or short-lived enzymes that fail to persist in the body. In neuronopathic Gaucher disease, the lysosomal enzyme glucocerebrosidase (GCase) is defective, and both enzyme replacement and gene therapy attempts have been limited by instability and poor distribution in the...]]></description><link>https://www.scala-bio.com/post/stabilizing-glucocerebrosidase-for-gaucher-disease-gene-therapy</link><guid isPermaLink="false">68d3eda2b43801901d450c4d</guid><category><![CDATA[Biotherapeutics]]></category><pubDate>Fri, 31 Oct 2025 14:28:51 GMT</pubDate><enclosure url="https://static.wixstatic.com/media/cecc39_3239ce66fdef495ea4f61ac215773612~mv2.jpg/v1/fit/w_1000,h_800,al_c,q_80/file.png" length="0" type="image/png"/><dc:creator>gilishklar</dc:creator></item><item><title><![CDATA[Simultaneous optimization of antibody developability &#38; humanness]]></title><description><![CDATA[Scala’s one-round computational humanization generates diverse, fully human antibodies with preserved activity Why it matters Classical antibody humanization methods often compromise expression, stability, or function and require lengthy iterative back-mutation cycles. Scala’s CUMAb technology introduces a systematic, computation-driven alternative. By testing thousands of possible human frameworks in silico, CUMAb produces a diverse panel of fully human antibodies predicted to be stable,...]]></description><link>https://www.scala-bio.com/post/simultaneous-optimization-of-antibody-developability-humanness</link><guid isPermaLink="false">68e3aaa23af439b9bda2cbf4</guid><category><![CDATA[Biotherapeutics]]></category><pubDate>Thu, 30 Oct 2025 13:11:29 GMT</pubDate><enclosure url="https://static.wixstatic.com/media/cecc39_d501b3af47914f87a842e9de180fed70~mv2.jpg/v1/fit/w_1000,h_800,al_c,q_80/file.png" length="0" type="image/png"/><dc:creator>gilishklar</dc:creator></item><item><title><![CDATA[Improving catalytic activity and selectivity]]></title><description><![CDATA[Scala’s active-site design software enabled a cytochrome P450 to reach industrially relevant activity, supporting sustainable chemical production In collaboration with: Why it matters Industrial enzymes are central to greener chemical processes, but their activity is often too low for commercial use. In this case, a cytochrome P450 enzyme was redesigned to deliver a seven-fold boost in catalytic efficiency, demonstrating how Scala’s technology can rapidly optimize enzymes for industrial use,...]]></description><link>https://www.scala-bio.com/post/improving-catalytic-activity-and-selectivity</link><guid isPermaLink="false">68d3faac9a52887193bb3c95</guid><category><![CDATA[Biomanufacturing]]></category><pubDate>Wed, 29 Oct 2025 10:14:24 GMT</pubDate><enclosure url="https://static.wixstatic.com/media/cecc39_357df7a5c01641e29a8c8fafb21116ab~mv2.jpg/v1/fit/w_1000,h_1000,al_c,q_80/file.png" length="0" type="image/png"/><dc:creator>gilishklar</dc:creator></item><item><title><![CDATA[Co-optimizing stability and activity in a DNA processing enzyme]]></title><description><![CDATA[Scala’s stability design software improves activity and robustness of a DNA processing enzyme In collaboration with: Why it matters DNA synthesis at scale depends on specialized enzymes that are stable and reliable under demanding conditions. Many DNA processing enzymes are dynamic, multi-domain proteins whose limited stability constrains performance in synthesis workflows. When Scala’s stability design software was applied to one such enzyme, the resulting variants were not only more stable...]]></description><link>https://www.scala-bio.com/post/co-optimizing-stability-and-activity-in-a-dna-processing-enzyme</link><guid isPermaLink="false">68e3b4154a2f8583aa9a96d1</guid><category><![CDATA[Biomanufacturing]]></category><pubDate>Tue, 28 Oct 2025 13:28:14 GMT</pubDate><enclosure url="https://static.wixstatic.com/media/cecc39_8500c520b9244be8a7460aa29827c390~mv2.jpg/v1/fit/w_1000,h_1000,al_c,q_80/file.png" length="0" type="image/png"/><dc:creator>gilishklar</dc:creator></item><item><title><![CDATA[Designing enzymes with complementary enantioselectivity profiles]]></title><description><![CDATA[Scala’s underlying active-site design technology generates enantiodivergent, stable UPO variants Why it matters Enantioselectivity, the preference for one mirror-image product over another, is crucial in pharmaceuticals and fine chemicals, where the two forms often have very different effects. Yet controlling enantioselectivity is notoriously difficult. Scala’s underlying active-site design technology was applied to an unspecific peroxygenase (UPO), generating a stable and diverse repertoire...]]></description><link>https://www.scala-bio.com/post/enantioselectivity-use-case</link><guid isPermaLink="false">68e3b6373af439b9bda2e53a</guid><category><![CDATA[Biomanufacturing]]></category><pubDate>Mon, 27 Oct 2025 13:34:12 GMT</pubDate><enclosure url="https://static.wixstatic.com/media/cecc39_b60b4ad1a0d14c33a40836a9fbfb5288~mv2.jpg/v1/fit/w_1000,h_1000,al_c,q_80/file.png" length="0" type="image/png"/><dc:creator>gilishklar</dc:creator></item><item><title><![CDATA[Enabling microbial production of a human enzyme]]></title><description><![CDATA[Scala’s underlying computational design enables bacterial production of a complex human enzyme Why it matters Producing complex human enzymes in bacteria is a major hurdle for biotechnology, since many proteins are too unstable to fold and function outside human cells. Human acetylcholinesterase (AChE) is one such enzyme and resisted all attempts at bacterial production for more than 20 years. Scala’s stability design technology overcame this barrier, enabling high-yield production of active...]]></description><link>https://www.scala-bio.com/post/enabling-microbial-production-of-a-human-enzyme</link><guid isPermaLink="false">68e3b20f2849e99ade0d6ae1</guid><category><![CDATA[Biomanufacturing]]></category><pubDate>Sat, 25 Oct 2025 21:00:00 GMT</pubDate><enclosure url="https://static.wixstatic.com/media/cecc39_8d6dbad5a0934d58969f29e71365ed63~mv2.png/v1/fit/w_1000,h_800,al_c,q_80/file.png" length="0" type="image/png"/><dc:creator>gilishklar</dc:creator></item></channel></rss>